EXPERIMENTAL ROTAVIRUS INFECTION IN NEONATAL RATS

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Sequential changes in small intestinal structure and function during rotavirus infection in neonatal rats.

Rotavirus infection is the most common cause of acute diarrhoea in children worldwide. The structural and functional consequences of mammalian rotavirus infection in the small intestine have been incompletely studied and the mechanism of enterocyte damage poorly defined. This study used a neonatal rat model of group B rotavirus infection to study the natural history, clinical features, and the ...

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Cord blood and breast-milk antibodies in neonatal rotavirus infection.

Studies were carried out during an outbreak of rotavirus type 2 infection in a neonatal nursery to determine the protective role of antibodies in cord blood and breast milk. The range, distribution, and geometric mean titres of rotavirus-specific antibody in the cord blood were similar among rotavirus-positive and rotavirus-negative neonates, and the amount of virus excreted did not correlate w...

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Epidemiology of Rotavirus Infection in Certain Countries

Abstract Acute diarrhea with severe dehydration has been a major worldwide cause of death in children younger than 5 years of age. Etiological studies of gastroenteritis have shown that rotavirus causes 40–50% of acute diarrhea among infants and children in both developing and developed nations. Numerous epidemiologic studies in the US and the World Health Organization have docu...

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ROTAVIRUS INFECTION IN CHILDREN WITH ACUTE DIARRHEA IN TEHRAN

The etiology of acute diarrhea was studied in 915 children under 5 years of age between March 1986 and August 1987, in 7 hospitals in Tehran. 65 healthy children in similar age groups served as controls. Rotavirus was found in 25% of the patients and 1.5% of controls with the highest detection rate occurring in the 7-24 month age group (28%) and declining beyond 25 months of age (5%). The ...

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Rotavirus infection in adults.

Rotavirus has been recognised for 30 years as the most common cause of infectious gastroenteritis in infants and young children. By contrast, the role of rotavirus as a pathogen in adults has long been underappreciated. Spread by faecal-oral transmission, rotavirus infection in adults typically manifests with nausea, malaise, headache, abdominal cramping, diarrhoea, and fever. Infection can als...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1989

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-198909000-00103